3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Treatment Strategies and Perforation Rate of Acute Appendicitis During the Early Phase of the Covid-19 Pandemic: A Swedish Cohort StudyResearch article Published on 2022-12-012022-10-05 Journal: The Journal of surgical research [Category] 치료법, [키워드] 95% confidence interval Acute appendicitis Appendicitis association calculate Care Conservative management COVID-19 COVID-19 pandemic diagnosed early phase Frequency initial less multivariate logistic regression Odds ratio pandemic Patient patients hospitalized Perforation Perforation rate phase Rate receive resource Result risk severity single-center study South Strategy surgical Swedish Treatment Treatment strategies [DOI] 10.1016/j.jss.2022.07.007 [Article Type] Research article
Distinct immune responses in the early phase to natural SARS-CoV-2 infection or vaccinationArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] acute phase acute respiratory syndrome analyzed antibody Antibody Response coronavirus cytokine cytokine expression cytokine level Cytokines dose early phase elicited expression healthy IgA antibody immune response immunization implication inactivated Inactivated vaccine Inactivated Vaccines infected individuals natural infection nucleocapsid postvaccination Protein Reinfection response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 vaccines serological significant differences two groups vaccination vaccination. Vaccines variety viral infection [DOI] 10.1002/jmv.28034 PMC 바로가기
A novel method to monitor COVID-19 fatality rate in real-time, a key metric to guide public health policyArticle Published on 2022-10-312022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] applied approach changes in COVID-19 Delta driven by early phase Effect Epidemic Epidemics epidemiological data Fatality rate fused Germany high accuracy Infection MONITOR omicron pandemic public health required sensitivity vaccination Vaccine variant [DOI] 10.1038/s41598-022-23138-4 PMC 바로가기
Estimation of R0 for the spread of SARS-CoV-2 in Germany from excess mortalityArticle Published on 2022-10-142022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI calculated can be used contagious dataset death deaths determine early phase Effect estimate estimation Europe Germany growth growth factor incidence Infection lockdown measure Mortality much higher much lower office pandemic performed Robert Koch RT-PCR RT-PCR test RT-PCR testing SARS-CoV-2 Spread subject thought used data variant yielding [DOI] 10.1038/s41598-022-22101-7 PMC 바로가기
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 studyArticle Published on 2022-10-102022-11-15 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2. severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed [DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
Mindfulness and Defense Mechanisms as Explicit and Implicit Emotion Regulation Strategies against Psychological Distress during Massive Catastrophic EventsArticle Published on 2022-10-042022-11-15 Journal: International Journal of Environmental Research an [Category] 진단, [키워드] COVID-19 COVID-19 pandemic Defense defense mechanisms distress early phase emotion Emotion regulation emotional event explicit greater IES-R influence Interaction Italy limit massive mechanism mechanisms mindfulness moderate positive Post-traumatic stress symptoms predict predictor Psychological psychological health R 2 recruited Regulation response significantly social media platforms spread of COVID-19 Strategy Stress stress. stressful situations subjects Symptom were assessed [DOI] 10.3390/ijerph191912690 PMC 바로가기
Dynamic modulations of sphingolipids and glycerophospholipids in COVID-19Article Published on 2022-10-012022-11-15 Journal: Clinical and Translational Medicine [Category] 바이오마커, [키워드] Administered association biological properties Biomarker ceramide characteristic clinical phenotype conditions control subject coronavirus disease Course COVID-19 Critical CRP D-dimer decrease develop disease severity dynamic early phase glycerophospholipids heterogeneity heterogeneous Infectious disease Laboratory testing Lipidomics lysophosphatidylcholine mechanism mice modulation negative correlation Phosphatidylcholine positive Prevent responsible serum severe COVID-19 severity shown sphingolipid sphingolipids sphingolipids. sphingomyelin subject subjects suppress tissue treated unsaturated [DOI] 10.1002/ctm2.1069 PMC 바로가기
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 sACE2. SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
Scars of COVID-19: A bibliometric analysis of post-COVID-19 fibrosisArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Public Health [Category] SARS, 치료기술, [키워드] acute injury Analysis analyzed article changed Cluster collected Comorbidities coronavirus 2 coronavirus disease country COVID-19 COVID-19 pandemic Cystic database Diagnosis early phase English enrolled Epidemiology etiology Evidence experiment fibrosis French hotspot hotspots and trends Imperial College London Increasing individual level Infection international cooperation intrinsic investigated journal Laboratory Lung function material novel Pathogenesis Patient professional promote public health threat Quality of life Research reversed Spread Therapies therapy Therapy. university University of Washington USA vaccination Volume was performed Web of Science [DOI] 10.3389/fpubh.2022.967829 PMC 바로가기